Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Rowe JM, Buck G, Burnett AK, Chopra R, Wiernik PH, Richards SM, et al. Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. Kantarjian H, Thomas D, O’Brien S, Cortes J, Giles F, Jeha S, et al. This comprehensive review will focus on the recent advances and future directions in novel therapeutic strategies in adult ALL.Īcute lymphoblastic leukemia Blinatumomab Chimeric antigen receptor Inotuzumab ozogamicin Monoclonal antibody. These highly effective new agents are allowing for novel approaches that reduce reliance on intensive cytotoxic chemotherapy and hematopoietic stem cell transplantation in first remission. The treatment paradigms of ALL have been revolutionized with the advent of tyrosine kinase inhibitors targeting BCR-ABL1, monoclonal antibodies targeting CD20 (rituximab), antibody-drug conjugates targeting CD22 (inotuzumab ozogamicin), bispecific antibodies (blinatumomab), and CD19 chimeric antigen receptor T cell therapy (tisagenlecleucel). The emergence of the concept of measurable residual disease has fine-tuned our prognostic models and guided our treatment decisions. OL5169902W Pages 274 Pdf_module_version 0.0.19 Ppi 300 Republisher_date 20200229192049 Republisher_operator Republisher_time 351 Scandate 20200221180209 Scanner Scanningcenter cebu Scribe3_search_catalog marygrove Scribe3_search_id 31927001041448 Tts_version 3.Recent years have witnessed major advances that have improved outcome of adults with acute lymphoblastic leukemia (ALL).
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(Too large, Full frame)Īccess-restricted-item true Addeddate 15:03:28 Associated-names Birren, Faber, 1900-1988 Bookplateleaf 0006 Boxid IA1778920 Camera Sony Alpha-A6300 (Control) Collection_set printdisabled External-identifier Number of pages are cut due to the size of the book. Tropez - Frontispiece of modern chromatics - II: The book, modern chromatics - Commentary notes by Faber Birren - III: Facsimile of modern chromatics, first American edition, 1879 Eugène Delacroiz, The massacre of Scio - Claude Monet, Poplars of Giverny - Camille Pissarro, River, Early morning - Vincent van Gogh, A corner in the park - Georges Seurat, Sunday on the Island of La Grande Jatte - Georges Seurat, detail, LaGrande Jatte - Paul Signac, Place de Lice, St. I: Ogden Nicholas Rood, his life / Ronald Rood - Impressionism / Eugène Delacroix, Claude Monet, Pierre Auguste Renoir - Neo-Impressionism / Camille Pissarro, Georges Seurat, Paul Signac, other Neo-Impressionist painters - Fauvism - Other influences / Charles Blanc, David Sutter, Charles Henry - Rood's influence in America - Technical evaluation : The problem of tritanopia - I. Includes bibliographical references (pages 60-61)
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26 of The International scientific series reads: Modern chromatics, with applications to art and industry, by Ogden N.
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